T-SPOT.TB Reactivity in Southern African Children With and Without in Utero HIV Exposure

Saori C. Iwase,Paul T. Edlefsen,Lynnette Bhebhe, Kessy Motsumi,Sikhulile Moyo,Anna‐Ursula Happel,Danica Shao, Nicholas Mmasa,Sara Schenkel,Melanie A. Gasper,Melanie Dubois,Megan Files,Chetan Seshadri,Fergal J. Duffy,John D. Aitchison,Mihai G. Netea,Jennifer Jao,D. William Cameron,Clive M. Gray,Heather B. Jaspan,Kathleen M. Powis

Clinical Infectious Diseases（2023）

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摘要

Infants who are human immunodeficiency virus (HIV)-exposed uninfected (iHEU) experience higher risk of infectious morbidity than infants HIV-unexposed uninfected (iHUU). We compared tuberculosis (TB) infection prevalence in 418 Bacillus Calmette-Guérin vaccinated sub-Saharan African iHEU and iHUU aged 9-18 months using T-SPOT.TB. Prevalence of TB infection was low and did not differ by HIV exposure status.

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hiv,t-spottb,southern african children

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