Synchronous sporadic well-differentiated liposarcoma of the larynx and ductal carcinoma-in-situ in a young female

We report the case of a 39-year-old female with a left aryepiglottic fold mass presenting as a two-month history of globus sensation. Laser excision and subsequent biopsy revealed a well-differentiated liposarcoma. Three months later, an incidental finding of a left breast mass on PET scan turned out to be malignant. She underwent neoadjuvant chemotherapy and subsequent modified radical mastectomy with a histopathological diagnosis of ductal carcinoma in-situ. Due to the presence of synchronous malignancies in a young patient, a genetic cancer predisposition syndrome was entertained, primarily Li-Fraumeni syndrome (LFS). Genetic testing for TP53 gene mutation for LFS and other genetic cancer predisposition syndromes turned out to be negative.The patient currently has with no signs of tumor recurrence. To our knowledge this is the first documented case of synchronous non-genetic multiple primary malignant tumors of the larynx and the breast, of a liposarcoma and ductal carcinoma in-situ respectively.