Synthesis of anion-binding molecules towards novel benzothiazinones

Abstract Herein we report the synthesis of a set of novel N -benzoylthioureas, 2-(acyl)amino-4 H -3,1-benzothiazin-4-ones and thiourea derivatives with amino acid moieties. The corresponding benzoyl isothiocyanates were synthesised from a variety of substituted benzoyl chlorides with ammonium thiocyanate or from benzoic acids with the trichloroisocyanuric acid/triphenylphosphine (TCCA/TPP) system. The resulting compounds were reacted with substances containing amino groups to give new molecules with thiourea functionalities, which could be potential chloride ion binders.