Analysis of the progression-free survival of patients with oropharyngeal carcinoma depending on the detection of high-risk-HPV-specific DNA and p16-overexpression in the tumor tissue

Background Detection of p16 overexpression using immunohistochemistry is the required test method of the current 8th edition of the TNM-classification to detect HPV-induced carcinogenesis. Due to it′s moderate specificity, however, p16 testing alone is only sufficient to a limited extent.