Prevention and Treatment of Neonatal Hypothermia through an Implementation Science Study in Jaltenango Chiapas, Mexico

Abstract Introduction: Neonatal Hypothermia is preventable but common, contributing to neonatal morbidity and mortality especially in low resource settings. Kangaroo Mother Care (KMC) is the preferred method to prevent hypothermia, but relying on it as a continuous heat source is challenging. Other sources of external heat designed for low resource settings are an important potential complement to KMC. This study introduced a novel Infant Warmer in a low resource community hospital through an implementation science approach. Methods: We conducted a prospective, interventional cohort study in Jaltenango Chiapas, Mexico from January to November 2022. Our intervention was 1) an educational program about the importance of euthermia and optimal thermoregulatory practices including KMC, and 2) provision of an Infant Warmer designed for low-resource settings with training of healthcare providers. Our hypothesis was that neonatal hypothermia rates would decrease after our intervention. Our aims were to reduce hypothermia, and increase knowledge and confidence regarding neonatal thermoregulation. The study had three phases: Pre-Intervention, Intervention, and Warmer Use. We collected clinical data during the Pre-Intervention and Warmer Use Phases, including temperature on admission and six hours later (called “Follow-Up”). At three-time points we conducted surveys of healthcare providers regarding their knowledge of hypothermia, confidence in keeping newborns warm, and attitudes regarding the Warmer. We also conducted a Parent Survey. Results: We studied 372 newborns. Comparing Pre-Intervention to Warmer Use Phases, rates of hypothermia decreased from 62% to 27% on admission, and 59% to 11% on Follow-Up. The mean admission and Follow-Up temperatures increased by 0.06°C and 0.23°C (p=0.003) respectively. Healthcare providers' knowledge of hypothermia and confidence in keeping newborns warm also improved throughout the study. Conclusion: We found high baseline rates of neonatal hypothermia in this low resourced hospital. We successfully lowered rates and improved knowledge of hypothermia by providing education and appropriate thermoregulatory equipment to complement KMC. IRB-P00043372.