Combination of DNA methylation biomarkers with multiparametric magnetic resonance and ultrasound imaging fusion biopsy to detect the local spread of prostate cancer.

Augustinas Matulevičius,Kristina Žukauskaitė, Rugilė Gineikaitė, Darius Dasevičius,Mantas Trakymas,Ieva Naruševičiūtė,Jurgita Ušinskienė,Albertas Ulys,Feliksas Jankevičius,Sonata Jarmalaitė

The Prostate（2023）

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摘要

Thus, this study suggests that for focal therapy by region target hemi-ablation, the safe distance from the index lesion is no less than 10 mm. Noninvasive urine DNA methylation tests in combination with PSAD could be used for further follow-up of the patients, but larger prospective studies with external validation are needed.

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关键词

PCa focal therapy,epigenetic biomarkers,mpMRI/US,prostate cancer

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