Stochastic epithelial-mesenchymal transitions diversify non-cancerous lung cell behaviours

Sugandha Bhatia,Jennifer H Gunter,Joshua T Burgess,Mark N Adams, Kenneth O'Byrne,Erik W Thompson,Pascal HG Duijf

TRANSLATIONAL ONCOLOGY（2023）

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摘要

•Lung epithelial cell-derived single-cell clones display phenotypic heterogeneity.•Morphologically mesenchymal single cell-derived clones display altered EMP marker expression.•Lung epithelial cell-derived clones do not display genetic alterations.•Single cell-derived clones show diversity in their metabolic reflux, with increased glycolytic index in many of the clones.

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关键词

Clonal diversity,Epigenetics,Epithelial-mesenchymal transition (EMT),Epithelial-mesenchymal plasticity (EMP),Intra-tumour heterogeneity,Metabolic reprogramming

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