Higher docosahexaenoic acid levels lower the protective impact of eicosapentaenoic acid on long-term major cardiovascular events.

Viet T Le,Stacey Knight,Jeramie D Watrous,Mahan Najhawan,Khoi Dao,Raymond O McCubrey,Tami L Bair,Benjamin D Horne,Heidi T May,Joseph B Muhlestein,John R Nelson,John F Carlquist,Kirk U Knowlton,Mohit Jain,Jeffrey L Anderson

Frontiers in Cardiovascular Medicine（2023）

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摘要

Higher levels of EPA, but not DHA, are associated with a lower risk of MACE. When combined with EPA, higher DHA blunts the benefit of EPA and is associated with a higher risk of MACE in the presence of low EPA. These findings can help explain the discrepant results of EPA-only and EPA/DHA mixed clinical supplementation trials.

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关键词

EPA,DHA,major adverse cardiovascular events,omega-3,outcomes

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