Genetic and Epigenetic Associations with Pre-COPD Lung Function Trajectories.

David J Martino,Dinh S Bui,Shuai Li,Sabrina Idrose,Jennifer Perret,Adrian Lowe,Caroline Lodge,Gayan Bowatte,Yuben Moodley,Paul S Thomas,Graeme Zosky,Phillip M Hansbro,John Holloway,Cecile Svanse,Rosa Faner,Eugene H Walters, Shaymali C Dharmage

American journal of respiratory and critical care medicine（2023）

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摘要

High risk trajectories that progress to COPD exhibited genetic and epigenetic associations at epithelial and histocompatibility genes as well as accelerated epigenetic ageing.

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关键词

COPD,epigenetics,lung function,trajectories

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