Cancer risk in the siblings of individuals with major birth defects: a large Nordic population-based case-control study.

Dagrun Slettebø Daltveit,Kari Klungsøyr,Anders Engeland,Anders Ekbom,Mika Gissler,Ingrid Glimelius,Tom Grotmol,Laura Madanat-Harjuoja,Anne Gulbech Ording,Henrik Toft Sørensen,Rebecca Troisi,Tone Bjørge

International journal of epidemiology（2023）

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摘要

Overall risk of cancer among individuals (aged 0-46 years) whose siblings had birth defects was not elevated, but the risk of childhood cancer (ages 0-19 years) was increased. Our novel findings are consistent with the common aetiologies of birth defects and cancer, such as shared genetic predisposition and environmental factors.

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Neoplasms,abnormalities,aetiology,epidemiology,risk,sibling

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