Type I collagen proteolysis by matrix metalloproteinase-2 contributes to focal adhesion kinase activation and vascular smooth muscle cell proliferation in the aorta in early hypertension.

Viviano Gomes de Oliveira Neves,Marcela M Blascke de Mello, Daniel Rodrigues,Laena Pernomian,Isadora Sousa de Oliveira,Juliana M Parente,Eliane Candiani Arantes,Rita Tostes,Michele M Castro

Vascular pharmacology（2023）

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摘要

Increase in MMP-2 activity proteolyzes type I collagen in the aortas of 2K1C rats and contributes to activate FAK and induces VSMC proliferation during the initial phase of hypertension.

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关键词

Collagen,Focal adhesion kinase,Matrix metalloproteinase-2,Vascular smooth muscle cells

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