Caspase 5 depletion is linked to hyper-inflammatory response and progeroid syndrome
GeroScience(2024)
摘要
A progeroid family was found to harbor a pathogenic variant in the CASP5 gene that encodes inflammatory caspase 5. Caspase 5-depleted fibroblasts exhibited hyper-activation of inflammatory cytokines in response to pro-inflammatory stimuli. Long-term intermittent hyper-inflammatory response is likely the cause of the accelerated aging phenotype comprised of earlier onset of common aging diseases, supporting inflammaging as a potential common disease mechanism of progeroid syndromes and possibly normative aging.
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关键词
CASP5,Inflammation,Progeroid syndrome,Aging,Human,Genetic disorder
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