Palladium-catalyzed Heck-carbonylation of alkene-tethered carbamoyl chlorides with aryl formates.
Organic & biomolecular chemistry(2023)
摘要
We report a palladium-catalyzed Heck-carbonylation of alkene-tethered carbamoyl chlorides by utilizing aryl formates as convenient CO surrogates. One C-O and two C-C bonds are constructed to give diversiform esterified oxindoles/γ-lactams bearing an all-carbon quaternary stereocenter under gas-free conditions. This transformation features a wide substrate scope and good functional group tolerance and can be easily applied to late-stage functionalization.
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关键词
carbamoyl chlorides,palladium-catalyzed,heck-carbonylation,alkene-tethered
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