Increased liver stiffness promotes hepatitis B progression by impairing innate immunity in CCl4-induced fibrotic HBV + transgenic mice.

Grace Bybee,Youra Moeun,Weimin Wang,Kusum K Kharbanda,Larisa Y Poluektova,Srivatsan Kidambi,Natalia A Osna,Murali Ganesan

Frontiers in immunology（2023）

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摘要

Based on our data, we conclude that liver stiffness enhances OPN levels to limit anti-viral ISG activation in hepatocytes and promote an increase in HBV infectivity, thereby contributing to end-stage liver disease progression.

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关键词

liver stiffness,innate immunity,hbv+

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