Analysis of tumor infiltrating CD4+ and CD8+ CDR3 sequences reveals shared features putatively associated to the anti-tumor immune response.

Andrea Aran, Gonzalo Lázaro,Vicente Marco,Elisa Molina,Ferran Abancó,Vicente Peg,María Gión,Laia Garrigós,José Pérez-García,Javier Cortés,Mercè Martí

Frontiers in immunology（2023）

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摘要

Some differences between CD4+ and CD8+ TCRs were intrinsic to T cell subsets as can also be observed in peripheral T cells from healthy individuals, while other were only found in TILs samples and therefore may be tumor-driven. Notably, the higher similarity among CD4+ TCRs suggests a higher TCR promiscuity in this subset.

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关键词

immune response,cdr3 sequences,cd4+,cd8+,anti-tumor

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