Leukotriene signaling as molecular correlate for cognitive heterogeneity in aging: an exploratory study.

Heike Mrowetz,Mohamed H Kotob,Jennifer Forster, Iren Aydin,Michael Stefan Unger,Jana Lubec,Ahmed M Hussein,Jovana Malikovic,Daniel Daba Feyissa,Volker Korz,Harald Höger,Gert Lubec,Ludwig Aigner

Frontiers in aging neuroscience（2023）

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摘要

We conclude that 5-Lox expressing microglia potentially contribute to the age-related cognitive decline in the brain, while low levels of the LT system might indicate and foster higher cognitive functions and eventually cognitive reserve and resilience in aging.

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关键词

cognition, aging, microglia, 5-LOX, FLAP

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