Prognostic potential of thrombocyte indices, acute phase proteins, electrolytes and acid-base markers in canine parvovirus infected dogs with systemic inflammatory response syndrome.

Dogs with canine parvovirus enteritis (CPVE) that develop systemic inflammatory response syndrome (SIRS) frequently have a poor prognosis. The aim of the study was to assess the prognostic potential of thrombocyte indices, acute phase proteins, electrolytes and acid-base markers in CPVE puppies with SIRS (CPVE-SIRS+) at admission. A case-controlled, prospective and observational study was performed in 36 CPVE puppies. Mean concentrations of C-reactive protein (CRP), albumin, thrombocyte count, mean platelet volume (MPV), platelet distribution width (PDW), sodium (Na), (K), (Cl) and ionized calcium (iCa) were measured and strong ion difference 3 (SID) A and A were determined in CPVE-SIRS+ survivors and non-survivors. A prognostic cut-off value for predicting the disease outcome was determined by receiver operating characteristic (ROC) curve analysis. The mean values of MPV, PDW, CRP, albumin, Cl, and A showed significantly higher in CPVE-SIRS+ non-survivor than CPVE-SIRS+ survivor puppies on day of admission, but the thrombocyte count, Na, K, iCa, SID and A values did not differ significantly. The positive predictive values (PPVs) for survival using cut-off value of MPV (≤15.08 fL), PDW (≤14.85%), CRP (≤180.7mg/L), albumin (≥1.795 g/dL), Cl (≥96.00mmol/L), and A (≥7.539) were determined as 100%, 100%, 100%, 80%, 100% and 80%, respectively with better area under ROC curve and sensitivity. Based on sensitivity, specificity and PPVs from ROC analysis, it is concluded that determination of Cl concentration and MPV at admission followed by CRP will serve as the most appropriate biomarkers in predicting the disease outcome of CPVE puppies that develop SIRS.