Osteopontin levels correlate with severity of diabetic cardiomyopathy in early stage of diabetes.

Alessandro Scuricini,Francesco Andreozzi,Cosimo Sgura,Stefano Ministrini,Maria Bertolotto,Davide Ramoni,Luca Liberale,Giovanni G Camici,Gaia C Mannino,Elena Succurro,Giuseppe Armentaro,Teresa V Fiorentino,Velia Cassano,Sofia Miceli,Maria Perticone,Mariangela Rubino,Giorgio Sesti,Fabrizio Montecucco,Angela Sciacqua,Federico Carbone

Diabetes research and clinical practice（2023）

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摘要

Diabetic cardiomyopathy (DbCM) is characterized by restrictive pattern and consistent risk of overt heart failure. We here focused osteopontin (OPN), which was tested independently associated with left ventricular diastolic dysfunction (LVDD). Overall, OPN increased with DbCM severity according with the presence of left atrial dilatation, LV hypertrophy and LVDD.

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