Isorhamnetin Exerts Antifibrotic Effects by Attenuating Platelet-Derived Growth Factor-BB-induced HSC-T6 Cells Activation via Suppressing PI3K-AKT Signaling Pathway.

Mojtaba Rashidi,Emad Matour,Hasti Beheshti Nasab,Maryam Cheraghzadeh,Elham Shakerian

Iranian biomedical journal（2023）

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摘要

Our findings suggest that Isorhamnetin decreases HSC-T6 activation, the expression of COLA1 and α-SMA, in vitro, which could act as an antifibrotic element to reduce and treat liver fibrosis disease.

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