Utility of “flip-flop” chromatography employing silica hydride stationary phases with simultaneous photodiode array ultraviolet and single quadrupole mass detection for the analysis of seized drugs

•Silica hydride phase allows for uncorrelated multi-modal general drug screen.•All analytes retained for two under 10 min. isocratic separations.•%RSD less than 0.4% for retention times.•Rapid equilibration between separation modes.