Improved syntheses of P2X7 ligands based on substituted benzyl amide of pyroglutamic acid motif labelled with iodine-123 or iodine-125

Anna Marešová, Michal Jurášek,Tomáš Zimmermann, Pavel Drašar,Miloš Petřík, Petr Džubák,Sture Lindegren, Paul Cumming, Robert Pichler,Alexander Popkov

Journal of Radioanalytical and Nuclear Chemistry（2023）

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摘要

P2X7 sites are emerging targets for molecular imaging research, notably in the context of neurodegeneration and inflammatory conditions. Therefore, we prepared a precursor for (radio)iodination of the P2X7 ligand VPGIS191. We then developed a radioiodination method with 123I for SPECT with a radiochemical yield of 71 ± 13

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关键词

Radiopharmaceuticals,P2X7 receptor,Autoradiography,Single photon emission tomography

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