Dietary wheat amylase trypsin inhibitors exacerbate CNS inflammation in experimental multiple sclerosis.

Victor F Zevallos,Nir Yogev,Judith Hauptmann,Alexei Nikolaev,Geethanjali Pickert,Valeska Heib,Nicola Fittler,Sebastian Steven,Felix Luessi,Manjusha Neerukonda,Claudia Janoschka,Ann-Marie Tobinski,Luisa Klotz,Ari Waisman,Detlef Schuppan

Gut（2023）

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摘要

Dietary wheat ATI activate murine and human myeloid cells. The amount of ATI present in an average human wheat-based diet caused mild intestinal inflammation, which was propagated to extraintestinal sites, leading to exacerbation of CNS inflammation and worsening of clinical symptoms in EAE. These results support the importance of the gut-brain axis in inflammatory CNS disease.

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关键词

autoimmunity, brain, gut interaction, small intestine, nutrition, gluten free diet

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