Improving the safety of clinical management of COVID-19 patients receiving aminoglycosides and parenteral nutrition: Y-site compatibility studies.

Journal of pharmaceutical sciences(2023)

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摘要
In conclusion, our study showed that NOS was less prone to destabilization of oil-in-water systems by AMGs than SFK. In justified clinical cases, due to the lack of appearance of precipitate or enlarged lipid droplets, the combined administration of GM and AM with the NOS could be considered, provided tested volume ratios of the drug and MCB in the infusion line are maintained. However, it should be noted that such an infusion may be associated with the risk of changes in the pharmacokinetics of the drug.
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关键词
Aminoglycosides,COVID-19,Nutriflex omega special,Smofkabiven,Y-site administration,compatibility tests
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