Untangling the genetic traits underlying the development of copper toxicosis in Bedlington terriers.

Veterinary RecordVolume 193, Issue 4 p. 154-156 Research comment Untangling the genetic traits underlying the development of copper toxicosis in Bedlington terriers Lorna Kennedy, Corresponding Author Lorna Kennedy [email protected] Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, UKSearch for more papers by this authorBill Ollier, Bill Ollier Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, UKSearch for more papers by this author Lorna Kennedy, Corresponding Author Lorna Kennedy [email protected] Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, UKSearch for more papers by this authorBill Ollier, Bill Ollier Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, UKSearch for more papers by this author First published: 18 August 2023 https://doi.org/10.1002/vetr.3386Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. References 1Kim B-E, Nevitt T, Thiele DJ. Mechanisms for copper acquisition, distribution and regulation. Nat Chem Biol 2008; 4: 176–85 2Harris ED. Cellular copper transport and metabolism. Annu Rev Nutr 2000; 20: 291–310 3Hyun C, Filippich LJ. Inherited canine copper toxicosis in Australian Bedlington terriers. J Vet Sci 2004; 5: 19–28 4Haywood S, Boursnell M, Loughran MJ, et al. Copper toxicosis in non-COMMD1 Bedlington terriers is associated with metal transport gene ABCA12. J Trace Elem Med Biol 2016; 35: 83–9 5Hoffmann G, Ingh TSGAM, Bode P, et al. Copper-associated chronic hepatitis in Labrador retrievers. J Vet Intern Med 2006; 20: 856–61 6Kelly DF, Haywood S, Bennett AM. Copper toxicosis in Bedlington terriers in the United Kingdom. J Small Anim Pract 1984; 25: 293–8 7Smedley R, Mullaney T, Rumbeiha W. Copper-associated hepatitis in Labrador retrievers. Vet Pathol 2009; 46: 484–90 8Mandigers PJ, van den Ingh TS, Bode P, et al. Association between liver copper concentration and subclinical hepatitis in Doberman pinschers. J Vet Intern Med 2004; 18: 647–50 9Shearin AL, Ostrander EA. Leading the way: canine models of genomics and disease. Dis Model Mech 2010; 3: 27–34 10Yuzbasiyan-Gurkan V, Blanton SH, Cao Y, et al. Linkage of a microsatellite marker to the canine copper toxicosis locus in Bedlington terriers. Am J Vet Res 1997; 58: 23–7 11Tanzi RE, Petrukhin K, Chernov I, et al. The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene. Nat Genet 1993; 5: 344–50 12van de Sluis B, Rothuizen J, Pearson PL, et al. Identification of a new copper metabolism gene by positional cloning in a purebred dog population. Hum Mol Genet 2002; 11: 165–73 13Drumm ML, Ziady AG, Davis PB. Genetic variation and clinical heterogeneity in cystic fibrosis. Annu Rev Pathol 2012; 7: 267–82 14Haywood S, Swinburne J, Schofield E, et al. Copper toxicosis in Bedlington terriers is associated with multiple independent genetic variants. Vet Rec 2023; doi: 10.1002/vetr.2832 15Coronado VA, Damaraju D, Kohijoki R, et al. New haplotypes in the Bedlington terrier indicate complexity in copper toxicosis. Mamm Genome 2003; 14: 483–91 Volume193, Issue419 August–2 September 2023Pages 154-156 ReferencesRelatedInformation