The novel small molecule TPN10518 alleviates EAE pathogenesis by inhibiting AP1 to depress Th1/Th17 cell differentiation

Ling Xie,Jie Lv,Kaidireya Saimaier, Sanxing Han,Mengyao Han,Chun Wang,Guangyu Liu,Wei Zhuang,Xiangrui Jiang,Changsheng Du

International immunopharmacology（2023）

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摘要

•TPN10518 decreased inflammatory infiltration in the central nervous system (CNS).•TPN10518 diminished the production of Th1 and Th17 cells in vivo and in vitro.•TPN10518 reduced Th1 and Th17 cells through inhibition of AP1 in the treatment of multiple sclerosis (MS) mice.

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关键词

TPN10518,Th1/Th17 cells,AP1,Experimental autoimmune encephalomyelitis

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