Cell Surface Platelet Tissue Factor Expression: Regulation by P2Y 12 and Link to Residual Platelet Reactivity.

Marta Brambilla,Alessia Becchetti,Gianenrico Rovati,Nicola Cosentino,Maria Conti,Paola Canzano,Peter L A Giesen,Alessia Loffreda,Alice Bonomi,Marco Cattaneo,Erica De Candia,Gian Marco Podda,Daniela Trabattoni,Josè Werba,Jeness Campodonico,Christian Pinna,Giancarlo Marenzi,Elena Tremoli,Marina Camera

Arteriosclerosis, thrombosis, and vascular biology（2023）

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摘要

Data show that TF expression is regulated by P2Y and not P2Y; P2Y antagonists downregulate the percentage of TF-platelets. In clopidogrel good-responder patients, assessment of TF-platelets highlights those with residual platelet reactivity. TF is stored in open canalicular system, and its membrane exposure upon activation is prevented by colchicine.

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