Causal Role for Neutrophil Elastase in Thoracic Aortic Dissection in Mice.

Mei Yang,Xinmiao Zhou,Stuart W A Pearce, Zhisheng Yang,Qishan Chen,Kaiyuan Niu,Chenxin Liu,Jun Luo,Dan Li,Yue Shao,Cheng Zhang,Dan Chen,Qingchen Wu,Pedro R Cutillas, Lin Zhao,Qingzhong Xiao,Li Zhang

Arteriosclerosis, thrombosis, and vascular biology（2023）

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摘要

We unravel a critical role of NE and its target gene TBL1x in regulating inflammatory cell migration and smooth muscle cell phenotype modulation in the context of TAD. Our findings suggest that the NE-TBL1x signal axis represents a valuable therapeutic for treating high-risk TAD patients.

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关键词

neutrophil elastase,thoracic aortic dissection

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