m(6) A-Atlas v2.0: updated resources for unraveling the N 6-methyladenosine (m(6)A) epitranscriptome among multiple species

N (6)-Methyladenosine (m(6)A) is one of the most abundant internal chemical modifications on eukaryote mRNA and is involved in numerous essential molecular functions and biological processes. To facilitate the study of this important post-transcriptional modification, we present here m(6)A-Atlas v2.0, an updated version of m6A-Atlas. It was expanded to include a total of 797 091 reliable m(6) A sites from 13 high-resolution technologies and two single-cell m(6) A profiles. Additionally, three methods (exomePeaks2, MACS2 and TRESS) were used to identify >16 million m(6) A enrichment peaks from 2712 MeRIP-seq experiments covering 651 conditions in 42 species. Quality control results of MeRIP-seq samples were also provided to help users to select reliable peaks. We also estimated the condition-specific quantitative m6A profiles (i.e. differential methylation) under 172 experimental conditions for 19 species. Further, to provide insights into potential functional circuitry, the m(6) A epitranscriptomics were annotated with various genomic features, interactions with RNA-binding proteins and microRNA, potentially linked splicing events and single nucleotide polymorphisms. The collected m(6) A sites and their functional annotations