Immunogenicity and reactogenicity of fractional, heterologous primary COVID-19 vaccination schedules with BNT162b2 boosters in 5-11-year-old Thai children: A multicenter, prospective, double-blind, randomized control trial.

Orasri Wittawatmongkol,Pornumpa Bunjoungmanee,Pope Kosalaraksa,Kamolwish Laoprasopwattana,Sophida Boonsathorn,Napaporn Chantasrisawad,Tavitiya Sudjaritruk,Suvimol Niyomnaitham,Sansnee Senawong,Kanjana Srisutthisamphan,Zheng Quan Toh,Supattra Rungmaitree,Sira Nanthapisal,Supranee Phanthanawiboon,Puttichart Khantee,Chonnamet Techasaensiri,Nattiya Hirankarn, Sipang Pangprasertkul,Kulkanya Chokephaibulkit

Vaccine（2023）

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摘要

Standard and fractional heterologous regimens of CoronaVac-BNT162b2 induced similar or higher humoral immunity than homologous BNT162b2 and represent alternative vaccine regimens for children. These findings are highly relevant in settings concurrently using both vaccines.

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关键词

Paediatric vaccination,COVID-19 vaccines,Heterologous regimens,Homologous regimens,Fractional dosing,Paediatric boosters

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