Archived rilpivirine-associated resistance mutations among ART-naive and virologically suppressed people living with HIV-1 subtype C in Botswana: implications for cabotegravir/rilpivirine use.

Dorcas Maruapula,Natasha O Moraka,Ontlametse T Bareng,Patrick T Mokgethi,Wonderful T Choga,Kaelo K Seatla,Nametso Kelentse,Catherine K Koofhethille,Boitumelo J L Zuze,Tendani Gaolathe,Molly Pretorius-Holme,Joseph Makhema,Vlad Novitsky,Roger Shapiro,Sikhulile Moyo,Shahin Lockman,Simani Gaseitsiwe

The Journal of antimicrobial chemotherapy（2023）

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摘要

RPV-RAMs were present in 10.7% of ART-naive and 13.7% of ART-suppressed PWH in Botswana. The most common RPV-RAM in both groups was E138A. Since individuals with the E138A mutation may be more likely to fail cabotegravir/rilpivirine, monitoring RPV-RAMs will be crucial for effective cabotegravir/rilpivirine implementation in this setting.

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