Peptide-lipid hybrid vesicles with stimuli-responsive phase separation for controlled membrane functions.
Chemical communications (Cambridge, England)（2023）
摘要
A disulfide-tethered peptide-lipid conjugate self-assembled into a homogeneously distributed peptide-lipid hybrid vesicle. Upon dithiothreitol treatment, the homogeneous peptide-lipid membrane spontaneously divided into lipid-rich and peptide-rich domains, while the vesicle retained its size and shape. Membrane phase separation enhanced temperature-dependent cargo release.
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关键词
peptide–lipid hybrid vesicle,controlled membrane functions,phase separation,stimuli-responsive
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