Divergent patterns of healthy aging across human brain regions at single-cell resolution reveal links to neurodegenerative disease.

Establishment of a single nuclei atlas of human aging in four brain regionsEach region and cell type exhibits a unique aging-associated transcriptome signatureGene expression changes occur in absence of overt cell loss and are categorically unique across cell typesNeurological disease-associated genes have age-associated expression patterns in specific cell types in the context of healthy aging.