The proteome and phosphoproteome of circulating extracellular vesicle-enriched preparations are associated with characteristic clinical features in type 1 diabetes.

Anna Casu,Yury O Nunez Lopez,Gongxin Yu, Christopher Clifford,Anika Bilal,Alejandra M Petrilli, Heather Cornnell,Elvis Alvarez Carnero, Ananya Bhatheja,Karen D Corbin,Anton Iliuk,David M Maahs,Richard E Pratley

Frontiers in endocrinology（2023）

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摘要

This study demonstrates the potential of proteomic and phosphoproteomic signatures of EV-enriched preparations to provide insight into the pathobiology of T1D. The WGCNA analysis could be a powerful tool to discriminate signatures associated with different pathobiological components of the disease.

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extracellular vesicles, proteomics, phosphoproteomics, type 1 diabetes, human

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