Regulation of FGF2-induced proliferation by inhibitory GPCR in normal pituitary cells.

Liliana Del V Sosa,Florencia Picech,Pablo Perez,Silvina Gutierrez,Rodrigo Bainy Leal,Ana De Paul,Alicia Torres,Juan Pablo Petiti

Frontiers in endocrinology（2023）

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摘要

In summary, the GPCR-Gαi activated by SSTa blocked the pro-proliferative effect of FGF2 in normal pituitary cells a MEK-dependent mechanism, which acts as a mediator of both anti and pro-mitogenic signals, that may regulate the principal effectors of the G1 to S-phase transition.

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关键词

pituitary, FGF2, inhibitory GPCR, SST analog, S-phase

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