Intestinal Cckbr -specific knockout mouse as a novel model of salt-sensitive hypertension via sodium over-absorption.

Qiong-Yu Zhang, Yan Guo,Xiao-Liang Jiang,Xing Liu, Shu-Guang Zhao,Xian-Liang Zhou,Zhi-Wei Yang

Journal of geriatric cardiology : JGC（2023）

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摘要

These results support a crucial role of intestinal deficiency on SSH development and the diuretic antihypertension effect in CCKBR villin-Cre mice. The CCKBR villin-Cre mice with the high salt intake may serve as a stable model of salt-sensitive hypertensive induced by sodium overloading.

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