PERK Inhibition Suppresses Neovascularization and Protects Neurons During Ischemia-Induced Retinopathy.

Shuizhen Shi,Chun Ding,Shuang Zhu,Fan Xia,Seth E Buscho,Shengguo Li,Massoud Motamedi,Hua Liu,Wenbo Zhang

Investigative ophthalmology & visual science（2023）

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摘要

Our results demonstrate that PERK is involved in ischemia-induced retinopathy and its inhibition using GSK2606414 could offer an effective therapeutic intervention aimed at alleviating retinal NV while preventing neuron loss during retinal ischemia.

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关键词

ischemia-induced retinopathy, neovascularization, protein kinase RNA-activated-like ER kinase (PERK), endoplasmic reticulum (ER) stress, retina

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