Computer Simulation of the Coupling Between Recirculation Flows and Drug Release from a Coronary Drug-Eluting Stent
Biomedical Materials & Devices(2024)
摘要
This study examines the effect of recirculation zones and flow pulsatility on the transfer of the active ingredient from drug-eluting stents to the arterial wall, which can be hindered by recirculation zones located upstream and downstream of stent struts, leading to restenosis and thrombosis. Numerical simulations were conducted using a left coronary artery model with steady or pulsatile flows, and mass transfer analysis was performed on a single-stent strut with a square cross section. The findings offer valuable insights into optimizing the geometric design of drug-eluting stents by controlling the size and dynamics of induced recirculation cells, thereby enhancing the efficacy of stent treatments.
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关键词
Drug-eluting stent,Recirculation zones,Pulsatile flow,Mass transfer,Restenosis
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