lnc-β-Catm elicits EZH2-dependent β-catenin stabilization and sustains liver CSC self-renewal

Pingping Zhu, Yanying Wang,Guanling Huang,Buqing Ye,Benyu Liu,Jiayi Wu,Ying Du,Lei He,Zusen Fan

Nature Structural & Molecular Biology（2016）

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摘要

The lncRNA lnc-β-Catm associates with β-catenin and the methyltransferase Ezh2, thereby promoting β-catenin methylation and stabilization, which in turn lead to activation of Wnt–β-catenin signaling and promote liver CSCs self-renewal.

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self-renewal

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