Rbfox proteins regulate alternative mRNA splicing through evolutionarily conserved RNA bridges
Nature Structural & Molecular Biology(2013)
摘要
The Rbfox family of developmentally important splicing factors controls alternative splicing in a tissue-specific manner. Genome-wide analyses now show that more than half of Rbfox-binding sites are located distally from exons, that these distal sites are conserved and functionally important, and that long-range RNA-RNA secondary structures mediate distal splicing regulation by Rbfox.
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