Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects

Eva M Jimenez-Mateos,Tobias Engel,Paula Merino-Serrais,Ross C McKiernan,Katsuhiro Tanaka,Genshin Mouri,Takanori Sano,Colm O'Tuathaigh,John L Waddington,Suzanne Prenter,Norman Delanty,Michael A Farrell,Donncha F O'Brien,Ronán M Conroy,Raymond L Stallings,Javier DeFelipe,David C Henshall

Nature Medicine（2012）

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摘要

Temporal lobe epilepsy (TLE) is linked to neuron death in the hippocampus. Now David Henshall and colleagues show that miR-134 is upregulated in humans with TLE and in an experimental epilepsy model in mice. Decreasing miR-134 before induction of epilepsy in mice reduces neuron death and the generation of spontaneous seizures.

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