Stage-specific control of early B cell development by the transcription factor Ikaros

Tanja A Schwickert,Hiromi Tagoh,Sinan Gültekin,Aleksandar Dakic,Elin Axelsson,Martina Minnich,Anja Ebert,Barbara Werner,Mareike Roth,Luisa Cimmino,Ross A Dickins,Johannes Zuber,Markus Jaritz,Meinrad Busslinger

Nature Immunology（2014）

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摘要

The transcription factor Ikaros is required for lymphopoiesis. Busslinger and colleagues show Ikaros positively regulates genes encoding pre-BCR signal transducers and thereby promotes pro-B to pre-B cell progression and proliferation.

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