IL28B is associated with response to chronic hepatitis C interferon-α and ribavirin therapy

Vijayaprakash Suppiah,Max Moldovan,Golo Ahlenstiel,Thomas Berg,Martin Weltman,Maria Lorena Abate,Margaret Bassendine,Ulrich Spengler,Gregory J Dore,Elizabeth Powell,Stephen Riordan,David Sheridan,Antonina Smedile,Vincenzo Fragomeli,Tobias Müller,Melanie Bahlo,Graeme J Stewart,David R Booth,Jacob George

Nature Genetics（2009）

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摘要

Jacob George and colleagues report a genome-wide association study to hepatitis C treatment response. They report an association of common variants within the IL28B region to sustained virologic response following pegylated interferon alpha and ribavirin combined therapy in individuals with genotype 1 chronic hepatitis C.

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