The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation

Jing Wang,Sarah Hevi,Julia K Kurash,Hong Lei, Frédérique Gay,Jeffrey Bajko,Hui Su,Weitao Sun,Hua Chang,Guoliang Xu,François Gaudet,En Li,Taiping Chen

Nature Genetics（2008）

引用 608|浏览2

暂无评分

摘要

En Li and Taiping Chen and colleagues report that lysine specific demethylase 1 (LSD1, also known as AOF2) demethylates and stabilizes DNA methyltransferase 1 (Dnmt1), and that deletion of Aof2 in embryonic stem cells induces progressive loss of DNA methylation.

查看译文

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要