MYC as a regulator of ribosome biogenesis and protein synthesis

Jan van Riggelen,Alper Yetil,Dean W. Felsher

Nature Reviews Cancer（2010）

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摘要

Recently, MYC has been shown to serve as a direct regulator of ribosome biogenesis and therefore coordinates protein synthesis. Could the regulation of ribosome biogenesis by MYC be necessary for its role in tumorigenesis?

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