HDACi-dependent microenvironmental normalization overcomes tumor burden-induced T-cell exhaustion.

Andrew Nguyen,Dominique Brown,Ramya Krishnan,Donald Bastin,Li Deng,Lan Chen,Omar Salem,Scott R Walsh,Jonathan L Bramson,Yonghong Wan

Clinical cancer research : an official journal of the American Association for Cancer Research（2023）

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摘要

Tumor burden-induced pathway changes can be reversed through epigenetic reprogramming, enabling the conversion from T-cell exhaustion to effector lineage differentiation.

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