Mitochondrial pannexin1 controls cardiac sensitivity to ischaemia/reperfusion injury.

Olga M Rusiecka,Filippo Molica,Morten S Nielsen,Axel Tollance,Sandrine Morel,Maud Frieden,Marc Chanson,Kerstin Boengler,Brenda R Kwak

Cardiovascular research（2023）

引用 0|浏览5

暂无评分

摘要

Panx1-/- mice display decreased sensitivity to cardiac I/R injury, resulting in smaller infarcts and improved recovery of left ventricular function. This cardioprotective effect of Panx1 deletion seems to involve cardiac mitochondria rather than a reduced inflammatory response. Thus, Panx1 may represent a new target for controlling cardiac reperfusion damage.

查看译文

关键词

Heart, Mitochondria, Pannexin1, Ischemia, reperfusion

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要