PROX1 Inhibits PDGF-B Expression to Prevent Myxomatous Degeneration of Heart Valves.

Circulation research（2023）

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摘要

PROX1 antagonizes PDGF-B signaling partially via FOXC2 to maintain the extracellular matrix composition and prevent myxomatous degeneration of cardiac valves.

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关键词

aortic valve, endothelial cells, extracellular matrix, mitral valve, prolapse

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