Epigenetic Induction of Smooth Muscle Cell Phenotypic Alterations in Aortic Aneurysms and Dissections.

Abhijit Chakraborty,Yanming Li,Chen Zhang,Yang Li,Kimberly R Rebello,Shengyu Li, Samantha Xu,Hernan G Vasquez,Lin Zhang,Wei Luo,Guangyu Wang,Kaifu Chen,Joseph S Coselli,Scott A LeMaire,Ying H Shen

Circulation（2023）

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摘要

Our study reveals the dynamic epigenetic induction of SMC phenotypic alterations in AAD. DNA damage and cytosolic leakage drive SMCs from a contractile phenotype to an inflammatory phenotype.

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关键词

aortic aneurysms

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