Investigation of Human Intrathecal Solute Transport Dynamics Using a Novel in vitro Cerebrospinal Fluid System Analog.

Akari Seiner,Goutham Kumar Reddy Burla,Dev Shrestha, Mayumi Bowen,Joshua D Horvath,Bryn A Martin

Frontiers in neuroimaging（2022）

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摘要

The modeling approach allowed precisely controlled and repeatable parametric investigation of ITDD injection protocols and devices. In combination, the results predict that parametric changes in lumbar spine ITDD-injection related parameters and devices can alter %ID to the brain and be tuned to optimize therapeutic benefit to CNS targets.

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