Interruption of bile acid enterohepatic circulation inhibits glycogen synthesis and promotes hepatocellular carcinoma progression.

In recent years,increasing attention has been given to public health.Cancer and obesity are hot topics,in which glucose and lipid metabolism play an important role.Glycogen synthase GYS2 has been found to regulate glycogen metabolism in hepatocellular carcinoma(HCC)and is a potential prognostic factor and therapeutic target.1